Acetaminophen :: essays research papers

AcetaminophenIn the late 1800s it was notice that papa-amino-phenol, could reduce fever, only the drug was too toxic to use. A less(prenominal) toxic extract called acetophenetidin was later found to be however as effective barely also had pain-relieving properties. In 1949, it was learned that phenacetin was metabolized into an active but also less toxic drug, acetaminophen. Since then, acetaminophen has been interchange under many over the counter brand names, most touristy being Tylenol.Acetaminophen serves one basic purpose, to relieve pain. It is the main section in pain killers that relieve headaches. It also substitutes anesthesia in circumcision operating theatre because anesthesia often ejectnot be used on infants. Dr. Michael Weitzman and 2 separate doctors performed an experiment on an infant to test the effectiveness of the drug. The results were not identical, but there were change magnitudes in heart rate respiratory rate and crying. that the drug did much good as a pain sculptural relief after the surgery than before the surgery. Acetaminophen is ingested orally and is rapidly and altogether absorbed into the gastrointestinal tract. It works in about one hour. The coloured detoxifies 90% of it by mixing it with sulfuric acid, and an separate 3-5% is catabolized by enzyme reactions to the acid. The metabolites ar excreted in the urine. The dosage of the drug should be used according to the cartonful instructions. A 10 gm over dose in adults, one hundred forty mg for kids, can cause permanent liver damage. Also if you had average taken some other drugs , The acetaminophen may become more toxic since the drugs are catabolized in the liver. To protect yourself from injury, you should take 1 gram of vitamin C and Cysteine -a bodily antioxidant.The kidneys can be permanently damaged if you constantly take the drug over a long period of time. You can get all kinds of cancers such as heart, liver , kidney. 40 % increase There are no nutrient supplements known to protect against kidney damage, but some amino acids such as Taurine powder and divide of Vitamin E might help. Some people alternate the use of other OTC such as Aspirin, which also has other dangerous set up , but hopefully will reduce acetaminophen toxicity.